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Ren’an Wu, Ph.D

Professor of Chemistry
CAS “Hundred Talent Program”

National Chromatographic R&A Center
CAS Key Laboratory of Separation Sciences for Analytical Chemistry,
Dalian Institute of Chemical Physics (DICP),
Chinese Academy of Sciences (CAS),
Zhongshan Road 457#, Dalian 116023,
Liaoning Province,
P.R.China
E-mail: wurenan@dicp.ac.cn

Research Interests
    •  Novel monolithic columns
      1. Silica-organo hybrid monolithic column
      2. Monolithic column-based multi-dimensional nano-LC-MS/MS
      3. Monolithic column for online solid-phase extraction
      4. Monolithic column for enzymatic reactor 
    • Nanomaterials
      1. Core/shell magnetic nanoparticles for sample preparation
      2. Nanoparticles for on-plate analysis of MALDI-TOF-MS
      3. Nanomaterial-based enzymatic reactor
    • Nano-biotechnology and nanomedicine
      1. SWNTs-based drug delivery
      2. SWNTs-based magnetic resonance imaging
      3. Proteomics for nano-biotechnology and nanomedicine

Education
    • 2003-2006, Post-doctoral Research Associate, School of Public Health, University of North Carolina at Chapel Hill, USA.
    • 2002-2003, Post-doctoral Fellow, Max-Plank-Institute for dynamics of complex technical systems in Magdeburg, Germany.
    • 1999-2002. Doctoral Research in Analytical Chemistry, Dalian Institute of Chemical Physics, CAS, China

Honors & Distinctions
    • The recipient of“Hundred Talent Program”, Chinese Academy of Sciences, China, 2008.
    • The recipient of “Hundred, Thousand and Ten Thousand Talent Program”, Liaoning Province, China, 2009.
    • 1st Rank Award of China Association for Instrumental Analysis (CAIA) for Capillary Electrochromatography, 2001. 
    • The recipient of “551 Talent Program”, Wenzhou, Zhejiang Province, China, 2002.

Publications
  • Representative Papers
    1. Minghuo Wu, Ren’an Wu*, Zhenbin Zhang, Hanfa Zou*. Preparation and application of organic-silica hybrid monolithic capillary columns. Electrophoresis, 2011, 32, 105–115.
    2. Ruibin Li, Ren’an Wu*, Liang Zhao, Zhengyan Hu, Shujing Guo, Xiulian Pan, Hanfa Zou*. Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells. Carbon, 2011, 49, 1797-1805.
    3. Zhenbin Zhang, Minghuo Wu, Ren’an Wu*, Jing Dong, Junjie Ou, Hanfa Zou*. Preparation of Perphenylcarbamoylated β-Cyclodextrin-silica Hybrid Monolithic Column with “One-Pot” Approach for Enantioseparation by Capillary Liquid Chromatography. Analytical Chemistry, 2011, 83, 3616–3622.
    4. Sun, S., Ma, H., Han, G., Wu, R., Zou, H., Liu, Y. Efficient enrichment and identification of phosphopeptides by cerium oxide using on-plate matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis. Rapid Commun Mass Spectrom, 2011, 25 (13), 1862-1868.
    5. Qianhao Min1, Ren’an Wu1, Liang Zhao, Hongqiang Qin, Mingliang Ye, Jun-Jie Zhu*, Hanfa Zou*. Size-selective proteolysis on mesoporous silica-based trypsin nanoreactor for low-MW proteome analysis. Chemical Communications, 2010, 46, 6144–6146.
    6. Minghuo Wu, Ren’an Wu*, Ruibing Li, Hongqiang Qin, Jing Dong, Zhenbin Zhang, Hanfa Zou*. Polyhedral Oligomeric Silsesquioxane as a Cross-linker for Preparation of Inorganic-Organic Hybrid Monolithic Columns. Anal. Chem., 2010, 82, 5447–5454.
    7. Minghuo Wu, Yingzhuang Chen, Ren’an Wu*, Ruibing Lia, Hanfa Zou*, Bo Chen, Shouzhuo Yao. The synthesis of chloropropyl-functionalized silica hybrid monolithic column with modification of N,N-dimethyl-N-dodecyl- amine for capillary electrochromatography separation. Journal of Chromatography A, 2010, 1217, 4389–4394.
    8. Zhenbin Zhang, Ren’an Wu*, Minghuo Wu, Hanfa Zou*. Recent Progress of Chiral Monolithic Stationary Phases in Capillary Electrochromatography and Capillary Liquid Chromatography. Electrophoresis, 2010, 31, 1457–1466.
    9. Ruibin Li, Ren’an Wu*, Liang Zhao, Minghuo Wu, Ling Yang, Hanfa Zou*. P-glycoprotein Antibody Functionalized Carbon Nanotube Overcomes the Multidrug Resistance of Human Leukemia Cells. ACS Nano, 2010, 4, 1399–1408.
    10. Zhiyuan Yu, Ren’an Wu*, Minghuo Wu, Liang Zhao, Ruibin Li, Hanfa Zou*. Preparation of polyamine-functionalized copper specific adsorbents for the selective adsorption of copper. Colloids and Surfaces B-Biointerfaces, 2010, 78, 222–228.
    11. Yu Zhang, Chen Chen, Hongqiang Qin, Ren’an Wu, Hanfa Zou*. The Synthesis of Ti-Hexagonal Mesoporous Silica for Selective Capture of Phosphopeptides. Chem. Comm. 2010, 12, 2271–2273.
    12. Minghuo Wu, Ren’an Wu*, Fangjun Wang, Lianbing Ren, Jing Dong, Zhen Liu, Hanfa Zou*. “One-Pot” Process for Fabrication of Organic-Silica Hybrid Monolithic Capillary Columns Using Organic Monomer and Alkoxysilane. Anal. Chem., 2009, 81, 3529–3536.
    13. Ruibin Li, Ren’an Wu, Minghuo Wu, Hanfa Zou*, Hong Ma, Ling Yang*, X. Chris Le. MEKC-LIF analysis of rhodamine123 delivered by carbon nanotubes in K562 cells. Electrophoresis, 2009, 30, 1906–1912.
    14. Peiyuan Wang, Liang Zhao, Ren’an Wu*, Hua Zhong, Hanfa Zou, Jie Yang, Qihua Yang*. Phosphonic Acid Functionalized Periodic Mesoporous Organosilicas and Their Potential Applications in Selective Enrichment of Phosphopeptides. Journal of Physical Chemistry C, 2009, 113(4): 1359-1366.
    15. Xiaoli Dong, Ren’an Wu*, Jing Dong, Minghuo Wu, Yan Zhu, Hanfa Zou*. Recent progress of polar stationary phases in capillary electrochromatography and capillary liquid chromatography. Electrophoresis, 2009, 30(1):141-54.
    16. Xiaoli Dong, Ren’an Wu*, Jing Dong, Minghuo Wu, Yan Zhu, Hanfa Zou*. The covalently bonded cellulose tris(3,5-dimethylphenylcarbamate) on a silica monolithic capillary column for enantioseparation in capillary electrochromatography, Journal of Chromatography B, 2008, 875, 317-322.
    17. Xiaoli Dong, Ren’an Wu*, Jing Dong, Minghuo Wu, Yan Zhu, Hanfa Zou*. A mesoporous silica nanoparticles immobilized open-tubular capillary column with a coating of cellulose tris(3,5-dimethylphenyl-carbamate) for enantioseparation in CEC. Electrophoresis, 2008, 29, 3933-3940.
    18. Liang Zhao, Ren’an Wu*, Guanghui Han, Houjiang Zhou, Lianbing Ren, Ruijun Tian, Hanfa Zou*. Highly selective enrichment of phosphopeptide on zirconium phosphonate-modified magnetic Fe3O4 nanoparticles. Journal of the American Society for Mass Spectrometry, 2008, 19, 1176–1186.
    19. Xiaoli Dong, Ren’an Wu*, Jing Dong, Minghuo Wu, Yan Zhu, Hanfa Zou*. Polyacrylamide-based monolithic capillary column with coating of cellulose tris(3,5-dimethylphenyl-carbamate) for enantiomer separation in capillary electrochromatography.. Electrophoresis, 2008, 29(4):919-27.
    20. Ren’an Wu, Lianghai Hu, Fangjun Wang, Mingliang Ye, Hanfa Zou*. Recent development of monolithic stationary phases with emphasis on microscale chromatographic separation. Journal of Chromatography A, 2008, 1184(1-2):369-92.
  • Books


    1 Ren’an Wu, Hanfa Zou. Monolithic Columns in Microscale Separations: Monolithic Chromatography and its Modern Applications, ISBN 978-1-906799-03-8, 215-264, 2010.


    2 Ruibin Li, Hanfa Zou, Hua Xiao and Renan Wu. Carbon Nanotubes Methods and Protocols: Chapter 13, Carbon nanotubes as intracellular carriers for multidrug resistant cells studies by capillary electrophoresis laser induced fluorescence.


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